Dihydopyrimidine dehydrogenase deficiency and tongue squamous cell carcinoma does relate in a particular way. To begin with, dihydropyrimidine dehydrogenase deficiency causes 5-Fluorouracil toxicity. Notably, dihydropyrimidine dehydrogenase is an enzyme that helps in the metabolism of 5-Fluorouracil. Therefore, the absence of this enzyme makes it difficult to metabolize the drug. As such, it becomes very difficult to treat diseases such as tongue squamous cell carcinoma. Thus, even with the administration of the right drug to the patients, there still exist high mortality rates. As a result, understanding the concept behind dihyropyrimidine dehydrogenase deficiency is very vital to clinicians. With this knowledge, they can help save the lives of several cancer patients.
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SIGNS OF DIHYDROPYRIMIDIONE DEHYDROGENASE DEFICIENCY
Dihydropyrimidine dehydrogenase deficiency is usually characterized by several signs and symptoms. Mostly, the symptoms manifest as neurological deficits. However, this is more common in infants. Firstly, among the symptoms include seizures. Research shows that the disease interferes with the metabolism of some compounds such as uracil. Thus, this causes poor neurological coordination which may result to seizures. Furthermore, the poor metabolism also makes it difficult to treat cancerous diseases such as tongue squamous cell carcinoma. Additionally, the disease also presents with intellectual disability. The poor neurological control makes an individual have a decrease in cognitive functions. Therefore, with the decrease in cognitive function, an individual is unable to reason well. This further causes high mortality rates among the patients.
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TREATMENT OF TONGUE SQUAMOUS CELL CARCINOMA
There exist several treatment modalities for this cancerous disease. To begin with, clinicians can opt for chemotherapy. This may involve the use of such drugs as 5-Fluorouracil. However, caution must be taken in cases of dihydropyrimidine dehydrogenase deficiency. Research shows that the disease reduces the metabolism of the drug. Thus, without consideration, the drug will be less effective in the management of tongue squamous cell carcinoma. Additionally, surgery may also help in the management of the cancer. The surgery aims at removing the cancerous cells and leaving the healthy ones. Furthermore, radiotherapy is also essential in the management of the disease. It is given mainly post-surgery to help prevent recurrence and avoid high mortality rates.
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